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Product Name phospho-FOXO6 (Ser184) Chinese Name 磷酸化叉头蛋白O6抗体 Alias Foxo6 (phospho Ser184); Foxo6 (phospho S184); Forkhead box protein O6; FOXO6_HUMAN. literatures Specific References (1) | SL20061R has been referenced in 1 publications.[IF=4.932] Yi Ren. et al. Pravastatin attenuates sepsis-induced acute lung injury through decreasing pulmonary microvascular permeability via inhibition of Cav-1/eNOS pathway. Int Immunopharmacol. 2021 Nov;100:108077 WB ; Mouse.Research Area Cell biology transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Cow, Horse, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 51kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthesised phosphopeptide derived from human FOXO6 around the phosphorylation site of Ser184: AV(p-S)MD Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Murine Foxo6 is a member of the murine forkhead family of transcription factors. This family consists of over 30 members, the vast majority of which is important in embryonic development. These forkhead transcription factors may play a role in maintenance and survival of developing and adult neurons.
Function:
Transcriptional activator.
Subcellular Location:
Cytoplasmic and Nuclear. When phosphorylated, translocated from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors.
Post-translational modifications:
Phosphorylation of Ser-184 is be important in regulating the transacriptional activity.
Similarity:
Contains 1 fork-head DNA-binding domain.
SWISS:
A8MYZ6
Gene ID:
100132074
Database links:Entrez Gene: 100132074 Human
Entrez Gene: 329934 Mouse
Omim: 611457 Human
SwissProt: A8MYZ6 Human
SwissProt: Q70KY4 Mouse
Unigene: 277090 Mouse
Unigene: 190858 Rat
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