Product Name	PRMT1
Chinese Name	蛋白质精氨酸甲基转移酶1抗体
Alias	protein arginine methyltransferase 1; ANM 1; ANM1; complete cds; HCP 1; HCP1; Heterogeneous nuclear ribonucleoproteins methyltransferase like 2; Heterogeneous nuclear ribonucleoproteins methyltransferase like2; HMT 2; HMT1 (hnRNP methyltransferase; HMT1 (hnRNP methyltransferase S. cerevisiae) like 2; HMT1 (hnRNP methyltransferase S. cerevisiae)-like 2; HMT1 hnRNP methyltransferase like 2; HMT1 hnRNP methyltransferase-like 2 (S. cerevisiae); HMT2; HRMT1 L2; HRMT1L 2; HRMT1L2; Human mRNA for suppressor for yeast mutant; Human mRNA for suppressor for yeast mutant complete cds; Interferon receptor 1 bound protein 4; Interferon receptor 1 bound protein4; Interferon receptor 1bound protein 4; IR1 B4; IR1B 4; IR1B4; Mrmt 1; Mrmt1; PRMT 1; PRMT1; Protein arginine methyltransferase 1; Protein arginine N methyltransferase 1; Protein arginine N methyltransferase1; Protein arginine N-methyltransferase 1 (EC 2.1.1.-) (Interferon receptor 1-bound protein 4); R1B4; S. cerevisiae like 2; S. cerevisiae)-like 2; ANM1_HUMAN.
Research Area	Tumour  Cell biology  Chromatin and nuclear signals  Cyclin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	41kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PRMT1: 281-361/361
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	PRMTs are a family of proteins that either monomethylate or dimethylate the guanidino nitrogen atoms of arginine side chains. PRMT1 methylates Histone H4 on R3 and acts synergistically with p300/CBP to enhance transcriptional activation by nuclear receptors. PRMT1 also methylates a number of non-histone proteins such as the orphan nuclear receptor HNF4, components of the heterogeneous nuclear ribonucleoprotein (hnRNP) particle, interleukin enhancer-binding factor 3 (ILF3), and interferon alpha and beta receptors. This suggests roles for PRMT1 in transcriptional regulation, mRNA processing and signal transduction. PRMT1 is also a coactivator for p53, methylating histone H4 to facilitate p53-mediated transcription. Function: Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, PIAS1, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15 and EWS. Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. Together with dimethylated PIAS1, represses STAT1 transcriptional activity, in the late phase of interferon gamma (IFN-gamma) signaling. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates FOXO1 and retains it in the nucleus increasing its transcriptional acivity. Subunit: Homodimer and heterodimer with PRMT8. Individual homodimers can associate to form a homohexamer. Interacts with BTG1, BTG2, NFATC2IP and IFNAR1 (By similarity). Interacts with and methylates CHTOP, thereby enabling the interaction of CHTOP with the 5FMC complex (By similarity). Interacts with ILF3 and SUPT5H. Interacts with and methylates FOXO1, leading to the nuclear retention of FOXO1 and the stimulation of FOXO1 transcriptional activity. Methylation of FOXO1 is increased upon oxidative stress. Subcellular Location: Nucleus. Nucleus, nucleoplasm. Cytoplasm, cytosol. Note=Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction. Tissue Specificity: Widely expressed. Similarity: Belongs to the protein arginine N-methyltransferase family. SWISS: Q99873 Gene ID: 3276 Database links: Entrez Gene: 476411 Dog Entrez Gene: 3276 Human Entrez Gene: 15469 Mouse Entrez Gene: 60421 Rat Omim: 602950 Human SwissProt: Q99873 Human SwissProt: Q9JIF0 Mouse SwissProt: Q63009 Rat Unigene: 20521 Human Unigene: 27545 Mouse Unigene: 5870 Rat

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