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Product Name PADI1 Chinese Name 蛋白质精氨酸亚型1抗体 Alias HPAD10; Padi1; PADI1_HUMAN; PDI; PDI1; PAD1; Peptidylarginine deiminase I; protein arginine deiminase type I; Protein-arginine deiminase type I; Protein-arginine deiminase type-1. Research Area Tumour Cell biology Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 75kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PADI1 / PAD1: 461-560/663 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates filaggrin and keratin K1, which maintains hydration of the stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in hair follicle formation. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]
Function:
Catalyzes the deimination of arginine residues of proteins.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Epidermis, prostate, testis, placenta, spleen and thymus.
Similarity:
Belongs to the protein arginine deiminase family.
SWISS:
Q9ULC6
Gene ID:
29943
Database links:Entrez Gene: 29943 Human
Omim: 607934 Human
SwissProt: Q9ULC6 Human
Unigene: 412941 Human
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