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Product Name CUZD1 Chinese Name 雌激素调节基因1抗体 Alias CUB and zona pellucida-like domain-containing protein 1: CUB and ZP domain-containing protein 1: CUZD1: ERG-1: Transmembrane protein UO-44: UNQ224/PRO257: UO-44. Research Area Tumour immunology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 68kDa Cellular localization cytoplasmic The cell membrane Extracellular matrix Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SERF1: 61-160/607 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail CUZD1 is a 607 amino acid single-pass type I membrane protein that contains two CUB domains and a ZP (zona-pellucida) domain. Expressed in pancreas and epithelium of ovary, CUZD1 is found at high levels in ovarian tumors where it is thought to inhibit cell attachment and proliferation. CUZD1 is suggested to play a role in cell motility, cell-cell interactions and/or interactions with the extracellular matrices. Existing as three alternatively spliced isoforms, CUZD1 is encoded by a gene located on human chromosome 10. Making up 4.5% of the human genome, chromosome 10 encodes roughly 800 genes including PTEN, a tumor suppressor gene that has been linked to the development of Cowden syndrome. The chromosome 10 encoded gene ERCC6 is important for DNA repair and is linked to Cockayne syndrome which is characterized by extreme photosensitivity and premature aging.
Function:
CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.
Subcellular Location:
Cytoplasmic vesicle > secretory vesicle membrane. Associated with zymogen granule membranes.
Tissue Specificity:
Detected in pancreas and epithelium of ovary. Expressed at higher levels in ovarian tumors than in normal tissue.
Similarity:
Contains 2 CUB domains.
Contains 1 ZP domain.
SWISS:
Q86UP6
Gene ID:
50624
Database links:
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