Product Name	PC5/PC6
Chinese Name	激素原转化酶5/6抗体
Alias	FLJ11149; FLJ16215; hPC6; PC5; PC6; PC6A; PCSK5; PCSK5_HUMAN; Prohormone convertase 5; Proprotein convertase 5; Proprotein convertase 6; Proprotein convertase PC5; Proprotein convertase subtilisin/kexin type 5; Protease PC6; SPC6; Subtilisin/kexin like protease PC5; Subtilisin/kexin-like protease PC5.
Research Area	Cell biology  Signal transduction  Epigenetics  Ubiquitin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	194,101kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PC5/PC6: 361-460/1860 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER. It then sorts to the trans-Golgi network where a second autocatalytic event takes place and the catalytic activity is acquired. This encoded protein is widely expressed and one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It mediates posttranslational endoproteolytic processing for several integrin alpha subunits and is thought to process prorenin, pro-membrane type-1 matrix metalloproteinase and HIV-1 glycoprotein gp160. Alternative splicing results in multiple transcript variants, some of which encode distinct isoforms, including a protease packaged into dense core granules (PC5A) and a type 1 membrane bound protease (PC5B). [provided by RefSeq, May 2014] Function: Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Subcellular Location: Secreted. Tissue Specificity: Expressed in T-lymphocytes. Similarity: Belongs to the peptidase S8 family. Contains 1 homo B/P domain. Contains 1 PLAC domain. SWISS: Q92824 Gene ID: 5125 Database links: Entrez Gene: 5125 Human Entrez Gene: 18552 Mouse Entrez Gene: 116548 Rat Omim: 600488 Human SwissProt: Q92824 Human SwissProt: Q04592 Mouse SwissProt: P41413 Rat Unigene: 368542 Human Unigene: 3401 Mouse Unigene: 104002 Rat

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