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Product Name PARP10 Chinese Name 多腺苷二磷酸多聚酶PARP10抗体 Alias ADP ribosyltransferase diphtheria toxin like 10; ARTD10; PARP 10; Poly (ADP ribose) polymerase family member 10; Poly [ADP ribose] polymerase 10. Research Area Cell biology Signal transduction Epigenetics G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species Human, Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 110kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PARP10: 331-430/1025 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]
Function:
May play a role in cell proliferation. May be required for the maintenance of cell cycle progression.
Subcellular Location:
Nucleus.Cytoplasm.
Tissue Specificity:
Highly expressed in spleen and thymus. Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes. Low expression in heart, brain, placenta, lung, skeletal muscle, and colon.
Post-translational modifications:
Stimulated through its phosphorylation by CDK2. Acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions. Phosphorylation is suppressed in growth-arrested cells.
Similarity:
Contains 1 PARP catalytic domain.
SWISS:
Q53GL7
Gene ID:
84875
Database links:Entrez Gene: 84875 Human
Entrez Gene: 671535 Mouse
Omim: 609564 Human
SwissProt: Q53GL7 Human
Unigene: 348609 Human
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