Product Name	phospho-Rhodopsin (Ser334)
Chinese Name	磷酸化视网膜色素变性蛋白4抗体
Alias	Rhodopsin (phospho S334); p-Rhodopsin (phospho S334); CSNBAD1; MGC138309; MGC138311; OPN 2; OPN2; opsd; OPSD_HUMAN; Opsin 2; opsin 2; Opsin 2 rod pigment; Opsin-2; Opsin2; Retinitis Pigmentosa 4; Retinitis pigmentosa 4 autosomal dominant; RHO; Rhodopsin; RP 4; RP4.
Product Type	Phosphorylated anti
Research Area	Cell biology  Neurobiology  Signal transduction  Stem cells  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Rat, Rabbit, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	39kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthesised phosphopeptide derived from human Rhodopsin around the phosphorylation site of Ser334: EA(p-S)AT
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Retinitis pigmentosa is an inherited progressive disease which is a major cause of blindness in western communities. It can be inherited as an autosomal dominant, autosomal recessive, or X-linked recessive disorder. In the autosomal dominant form,which comprises about 25% of total cases, approximately 30% of families have mutations in the gene encoding the rod photoreceptor-specific protein rhodopsin. This is the transmembrane protein which, when photoexcited, initiates the visual transduction cascade. Defects in this gene are also one of the causes of congenital stationary night blindness. [provided by RefSeq, Jul 2008] Function: Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal. Subcellular Location: Membrane. Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to the rod outer segment (OS) photosensory cilia. Tissue Specificity: Rod shaped photoreceptor cells which mediates vision in dim light. Post-translational modifications: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. Contains one covalently linked retinal chromophore. DISEASE: Retinitis pigmentosa 4. Night blindness, congenital stationary, autosomal dominant 1 Similarity: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. SWISS: P08100 Gene ID: 6010 Database links: Entrez Gene: 6010 Human Entrez Gene: 212541 Mouse Entrez Gene: 24717 Rat Omim: 180380 Human SwissProt: P08100 Human SwissProt: P15409 Mouse SwissProt: P51489 Rat Unigene: 247565 Human Unigene: 2965 Mouse Unigene: 406156 Mouse Unigene: 92530 Rat

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