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Product Name RGS8 Chinese Name G protein signal转导调节因子8抗体 Alias Regulator of G Protein Signalling 8; Regulator of G-protein signaling 8; RGS8; RGS8_HUMAN. Research Area Cell biology Signal transduction G protein-coupled receptor G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Cow, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 21kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human RGS8: 1-100/180 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]
Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Preferentially binds to G(o)-alpha and G(i)-alpha-3.
Subcellular Location:
Cytoplasm.
Similarity:
Contains 1 RGS domain.
SWISS:
P57771
Gene ID:
85397
Database links:Entrez Gene: 85397 Human
Entrez Gene: 67792 Mouse
Omim: 607189 Human
SwissProt: P57771 Human
SwissProt: Q8BXT1 Mouse
Unigene: 20982 Human
Unigene: 458417 Human
Unigene: 379143 Mouse
Unigene: 89634 Rat
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