Product Name	RGS6
Chinese Name	G protein signal转导调节因子6抗体
Alias	FLJ43552; G protein signaling 6 regulator; GAP; GTPase activating protein; MGC142132; Regulator of G protein signaling 6; Regulator of G protein signalling 6; Regulator of G-protein signaling 6; RGS 6; RGS6; RGS6_HUMAN; S914.
Research Area	Cell biology  Signal transduction  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	54kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human RGS6: 401-472/472
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the RGS (regulator of G protein signaling) family of proteins, which are defined by the presence of a RGS domain that confers the GTPase-activating activity of these proteins toward certain G alpha subunits. This protein also belongs to a subfamily of RGS proteins characterized by the presence of DEP and GGL domains, the latter a G beta 5-interacting domain. The RGS proteins negatively regulate G protein signaling, and may modulate neuronal, cardiovascular, lymphocytic activities, and cancer risk. Many alternatively spliced transcript variants encoding different isoforms with long or short N-terminal domains, complete or incomplete GGL domains, and distinct C-terminal domains, have been described for this gene, however, the full-length nature of some of these variants is not known.[provided by RefSeq, Mar 2011] Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/Gbeta5 dimer. Subunit: Heterodimer with Gbeta5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity). Subcellular Location: Cytoplasm. Membrane. Similarity: Contains 1 DEP domain. Contains 1 G protein gamma domain. Contains 1 RGS domain. SWISS: P49758 Gene ID: 9628 Database links: Entrez Gene: 9628 Human Entrez Gene: 50779 Mouse Entrez Gene: 54295 Rat Omim: 603894 Human SwissProt: P49758 Human SwissProt: Q9Z2H2 Mouse SwissProt: P49801 Rat Unigene: 509872 Human Unigene: 153013 Mouse Unigene: 199537 Rat Unigene: 207298 Rat

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