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Product Name MCP-2 Chinese Name 单核细胞趋化蛋白2抗体(小鼠) Alias MCP2; CCL 8; CCL8; CCL8; CCL8_MOUSE; C-C motif chemokine 8; Chemokine CC Motif Ligand 8; Chemokine CC Motif Ligand 8; HC14; HC14; MCP-2; MCP-2(6-76); Monocyte chemoattractant protein 2; Monocyte Chemotactic Protein 2; Monocyte Chemotactic Protein 2; SCYA10; SCYA8; SCYA8; Small inducible cytokine A8 [Precursor]; Small-inducible cytokine A8. literatures Specific References (2) | SL1985R has been referenced in 2 publications.[IF=38.49] Nguyen, Khoa D., et al. "Circadian gene Bmal1 regulates diurnal oscillations of Ly6Chi inflammatory monocytes." Science 341.6153 (2013): 1483-1488. FCM ; Mouse.[IF=4.59] Terao, Mika, et al. "Local Glucocorticoid Activation by 11β-Hydroxysteroid Dehydrogenase 1 in Keratinocytes: The Role in Hapten-Induced Dermatitis."The American Journal of Pathology (2016). IHC-P ; Mouse.Research Area Cell biology immunology Developmental biology Chemokine Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Mouse, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 9kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse MCP-2: 20-97/97 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Jul 2008].
Function:
Chemotactic factor that attracts monocytes. This protein can bind heparin (By similarity).
Subunit:
Monomer or homodimer; in equilibrium (By similarity).
Subcellular Location:
Secreted.
Similarity:
Belongs to the intercrine beta (chemokine CC) family.
SWISS:
Q9Z121
Gene ID:
20307
Database links:Entrez Gene: 6355 Human
Entrez Gene: 20307 Mouse
Omim: 602283 Human
SwissProt: P80075 Human
SwissProt: Q9Z121 Mouse
Unigene: 271387 Human
Unigene: 42029 Mouse
Growth factors and hormones( Growth Factor and Hormones)
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