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Product Name phospho-RGS16 (Tyr168) Chinese Name 磷酸化G protein signal转导调节因子16抗体 Alias RGS16 (phospho Y168); p-RGS16 (phospho Y168); A28 RGS14; A28 RGS14P; A28-RGS14P; HGNC:9997; hRGS-r; OTTHUMP00000033147; Regulator of G protein signaling 16; Regulator of G protein signalling 16; Regulator of G-protein signaling 16; Retinal-specific RGS; Retinally abundant regulator of G protein signaling; Retinally abundant regulator of G-protein signaling; RGS 16; RGS R; RGS-R; Rgs14; RGS16; RGS16_HUMAN; RGSR. Product Type Phosphorylated anti Research Area Cell biology Signal transduction G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 23kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthesised phosphopeptide derived from human RGS16 around the phosphorylation site of Tyr168: DS(p-Y)PR Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene belongs to the 'regulator of G protein signaling' family. It inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits. It also may play a role in regulating the kinetics of signaling in the phototransduction cascade. [provided by RefSeq, Jul 2008]
Function:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. May play a role in regulating the kinetics of signaling in the phototransduction cascade.
Tissue Specificity:
Abundantly expressed in retina with lower levels of expression in most other tissues.
Post-translational modifications:
Palmitoylated on Cys-2 and/or Cys-12.
Phosphorylation on Tyr-168 upon EGFR stimulation. Enhanced GTPase accelerating (GAP) activity on G(i)-alpha.
Similarity:
Contains 1 RGS domain.
SWISS:
O15492
Gene ID:
6004
Database links:Entrez Gene: 6004 Human
Entrez Gene: 19734 Mouse
Omim: 602514 Human
SwissProt: O15492 Human
SwissProt: P97428 Mouse
Unigene: 413297 Human
Unigene: 181709 Mouse
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