Product Name	SLC25A38
Chinese Name	溶质载体家族蛋白25成员38抗体
Alias	FLJ20551; FLJ22703; S2538_HUMAN; slc25a38; Solute carrier family 25 member 38.
Research Area	Tumour  Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, Cow, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	34kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SLC25A38: 101-200/304
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of the mitochondrial carrier family. The encoded protein is required during erythropoiesis and is important for the biosynthesis of heme. Mutations in this gene are the cause of autosomal congenital sideroblastic anemia.[provided by RefSeq, Mar 2010] Function: Mitochondrial carrier required during erythropoiesis. Probably involved in the biosynthesis of heme, possibly by facilitating 5-aminolevulinate (ALA) production. May act by importing glycine into mitochondria or by exchanging glycine for ALA across the mitochondrial inner membrane. Subcellular Location: Mitochondrion inner membrane. Tissue Specificity: Preferentially expressed in erythroid cells. DISEASE: Defects in SLC25A38 are a cause of anemia sideroblastic pyridoxine-refractory autosomal recessive (PRARSA) [MIM:205950]. A form of sideroblastic anemia not responsive to pyridoxine. Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by iron-loaded mitochondria clustered around the nucleus. Similarity: Belongs to the mitochondrial carrier family. SLC25A38 subfamily. Contains 3 Solcar repeats. SWISS: Q96DW6 Gene ID: 54977 Database links: Entrez Gene: 512325 Cow Entrez Gene: 54977 Human Entrez Gene: 208638 Mouse Entrez Gene: 301067 Rat Entrez Gene: 100147784 Sheep Omim: 610819 Human SwissProt: Q5EAC0 Cow SwissProt: Q96DW6 Human SwissProt: Q91XD8 Mouse SwissProt: Q499U1 Rat SwissProt: S2538 Sheep Unigene: 369615 Human Unigene: 236656 Mouse Unigene: 21048 Rat
Product Picture	Sample: bone (Mouse) Lysate at 40 ug Primary: Anti-SLC25A38(SL19815R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 34kD Observed band size: 37kD Paraformaldehyde-fixed, paraffin embedded (Rat stomach); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SLC25A38) Polyclonal Antibody, Unconjugated (SL19815R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.

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