Product Name	SLC22A3
Chinese Name	溶质载体家族蛋白22成员A3抗体
Alias	EMT; EMT organic cation transporter 3; EMTH; Extraneuronal monoamine transporter; OCT 3; OCT3; Orct 3; Orct3; Organic cation transporter 3; S22A3_HUMAN; SLC22 A3; SLC22A 3; Slc22a3; Solute carrier family 22 (extraneuronal monoamine transporter) member 3; Solute carrier family 22 (organic cation transporter) member 3; Solute carrier family 22 member 3.
literatures	Specific References  (1)     |     SL19807R has been referenced in 1 publications. [IF=4.321] Ying Zhang. et al. mPEG2k-PCLx Polymeric Micelles Influence Pharmacokinetics and Hypoglycemic Efficacy of Metformin through Inhibition of Organic Cation Transporters in Rats. Mol Pharmaceut. 2021;XXXX(XXX):XXX-XXX  IF ;  Human.   PubMed:34102842
Research Area	Tumour  Cell biology  Neurobiology  Signal transduction  Transporter
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	61kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SLC22A3: 301-400/556
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. [provided by RefSeq, Jul 2008] Function: Mediates potential-dependent transport of a variety of organic cations. May play a significant role in the disposition of cationic neurotoxins and neurotransmitters in the brain. Subcellular Location: Membrane. Tissue Specificity: Expressed in placenta, skeletal muscle, prostate, aorta, liver, fetal lung, salivary gland, adrenal gland, kidney and brain cortex. No expression detected in spleen. Similarity: Belongs to the major facilitator superfamily. Organic cation transporter family. SWISS: O75751 Gene ID: 6581 Database links: Entrez Gene: 6581 Human Entrez Gene: 20519 Mouse Entrez Gene: 29504 Rat Omim: 604842 Human SwissProt: O75751 Human SwissProt: Q9WTW5 Mouse SwissProt: O88446 Rat Unigene: 567337 Human Unigene: 99252 Mouse Unigene: 24231 Rat

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