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Product Name SLC16A11 Chinese Name 溶质载体家族蛋白16成员A11抗体 Alias FLJ90193; MCT 11; Monocarboxylate transporter 11; MOT11_HUMAN; SLC16A11; Solute carrier family 16 member 11 (monocarboxylic acid transporter 11); Solute carrier family 16 member 11. Research Area Cell biology Signal transduction Diabetes Endocrinopathy Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 48kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SLC16A11: 331-430/471 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail SLC16A11 (Solute Carrier Family 16 Member 11) is a Protein Coding gene. GO annotations related to this gene include symporter activity and monocarboxylic acid transmembrane transporter activity. An important paralog of this gene is SLC16A7. Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.
Function:
Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Expressed in liver, salivary gland and thyroid.
DISEASE:
Disease susceptibility is associated with variations affecting the gene represented in this entry. Variants Ile-113, Gly-127, Ser-340 and Thr-443 are individually associated with a 20% increased risk of NIDDM. These variants are present at 50% frequency in Native-American samples, 10% in east Asian, while they are rare in European and African samples populations. These haplotypes probably derive from H.sapiens neanderthalensis (Neanderthal) introgression (PubMed:24390345).
Disease description:A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.
Similarity:
Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
SWISS:
Q8NCK7
Gene ID:
162515
Database links:Entrez Gene: 162515 Human
Entrez Gene: 216867 Mouse
Omim: 615765 Human
SwissProt: Q8NCK7 Human
SwissProt: Q5NC32 Mouse
Unigene: 336564 Human
Unigene: 289238 Mouse
Unigene: 89414 Rat
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