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Product Name RBM35B/ESRP2 Chinese Name RNABinding protein35B抗体 Alias Epithelial splicing regulatory protein 2; ESRP 2; ESRP2; ESRP2_HUMAN; FLJ21918; FLJ22248; RBM35B; RNA binding motif protein 35A; RNA binding motif protein 35B; RNA binding protein 35B; RNA-binding motif protein 35B; RNA-binding protein 35B. Research Area Cell biology Binding protein Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Cow, Rabbit, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 78kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human RBM35B/ESRP2: 21-120/727 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail ESPR2 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009]
Function:
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
Subcellular Location:
Nucleus.
Tissue Specificity:
Epithelial cell-specific.
Similarity:
Belongs to the ESRP family.
Contains 3 RRM (RNA recognition motif) domains.
SWISS:
Q9H6T0
Gene ID:
80004
Database links:
Entrez Gene: 80004 Human
Entrez Gene: 77411 Mouse
Omim: 612960 Human
SwissProt: Q9H6T0 Human
SwissProt: Q8K0G8 Mouse
Unigene: 436585 Human
Unigene: 592053 Human
Unigene: 183003 Mouse
Unigene: 137974 Rat
Unigene: 231924 Rat
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