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Product Name Matrilin 1 Chinese Name 软骨基质蛋白抗体 Alias Cartilage matrix protein; CMP; CRTM; Mat1; MATN1; Matrilin-1; MGC95132; Cartilage matrix protein 1. Research Area immunology Developmental biology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 55kDa Cellular localization Extracellular matrix Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Matrilin 1: 301-400/496 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins are thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. Mutations of this gene have been associated with variety of inherited chondrodysplasias. [provided by RefSeq]
Function:
Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen.
Subunit:
Homotrimer. Interacts with COMP.
Subcellular Location:
Secreted, extracellular space, extracellular matrix.
Similarity:
Contains 1 EGF-like domain.
Contains 2 VWFA domains.
SWISS:
P21941
Gene ID:
4146
Database links:Entrez Gene: 4146 Human
Entrez Gene: 17180 Mouse
Omim: 115437 Human
SwissProt: P21941 Human
SwissProt: P51942 Mouse
Unigene: 150366 Human
Unigene: 271796 Mouse
Unigene: 15159 Rat
Matrilins 是一组非胶原的Extracellular matrix蛋白家族,该蛋白家族分别为 Matrilin-1, Matrilin-2, Matrilin-3 和 Matrilin-4 。
Matrilnin-1 和 Matrilin-3 主要分布在生长的软骨组织中,Matrilin-2 和 Matrilin-4 分布较广,主要分布于软骨的增殖和肥大区,在软骨膜、骨膜及骨组织中,而且,它也分布在许多非骨组织中,如腱、韧带、真皮、心脏、平滑肌、消化道和呼吸道等。
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