Product Name	Netrin G2 Ligand
Chinese Name	脑瘤相关基因抗体
Alias	BAG; Brain tumor associated protein LRRC4; Brain tumor-associated protein BAG; Leucine rich repeat containing 4; Leucine rich repeat containing protein 4; Leucine-rich repeat-containing protein 4; Lrrc4; LRRC4_HUMAN; MGC133342; MGC133343; NAG14; Nasopharyngeal carcinoma associated gene 14 protein; Nasopharyngeal carcinoma-associated gene 14 protein; Netrin G2 ligand; Netrin-G2 ligand; NGL 2; NGL2; NGL-2; OTTHUMP00000212282; OTTHUMP00000212283; OTTHUMP00000212284.
literatures	Specific References  (1)     |     SL1974R has been referenced in 1 publications. [IF=8.886] Jianbo Feng. et al. LRRC4 mediates the formation of circular RNA CD44 to inhibit GBM cell proliferation. Mol Ther-Nucl Acids. 2021 Aug;:  WB ;  Human.   PubMed:10.1016/j.omtn.2021.08.026
Research Area	immunology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	68kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LRRC4: 501-600/653
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitement of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma. Function: Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity). Subunit: Interacts with NTNG2 (By similarity). Interacts with DLG4 (By similarity). Forms a complex with DLG4 and with NMDA receptors. Subcellular Location: Membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic cell membrane. Tissue Specificity: Specifically expressed in brain. Similarity: Contains 1 Ig-like (immunoglobulin-like) domain. Contains 9 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. SWISS: Q9HBW1 Gene ID: 64101 Database links: Entrez Gene: 64101 Human Entrez Gene: 192198 Mouse Entrez Gene: 641521 Rat Omim: 610486 Human SwissProt: Q9HBW1 Human SwissProt: Q99PH1 Mouse SwissProt: Q45R42 Rat Unigene: 655003 Human Unigene: 443660 Mouse Unigene: 198672 Rat

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