Product Name	Endophilin II
Chinese Name	胞吞蛋白Endophilin 2抗体
Alias	SH3 containing Grb 2 like 1 protein; Endophilin II; CNSA1; EEN; EEN fusion partner of MLL; Endophilin-2; Endophilin-A2; Extra 11 19 leukemia fusion gene; Extra eleven-nineteen leukemia fusion gene protein; Fusion partner of MLL; MGC111371; SH3 containing Grb 2 like 1 protein; SH3 containing protein EEN; SH3 domain GRB2 like 1; SH3 domain protein 2B; SH3 domain-containing GRB2-like protein 1; SH3D2B; SH3G1_HUMAN; SH3GL1; SH3P8.
Research Area	Tumour  Cell biology  immunology  Cyclin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	41kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Endophilin II: 31-130/368
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the endophilin family of Src homology 3 domain-containing proteins. The encoded protein is involved in endocytosis and may also play a role in the cell cycle. Overexpression of this gene may play a role in leukemogenesis, and the encoded protein has been implicated in acute myeloid leukemia as a fusion partner of the myeloid-lymphoid leukemia protein. Pseudogenes of this gene are located on the long arm of chromosomes 11 and 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011] Function: Implicated in endocytosis. May recruit other proteins to membranes with high curvature. Subcellular Location: Cytoplasm. Early endosome membrane. Associated with postsynaptic endosomes in hippocampal neurons. Tissue Specificity: Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus. DISEASE: Note=In some cases of acute leukemia, a translocation results in the formation of a MLL-EEN fusion gene. Similarity: Belongs to the endophilin family. Contains 1 BAR domain. Contains 1 SH3 domain. SWISS: Q99961 Gene ID: 6455 Database links: Entrez Gene: 512719 Cow Entrez Gene: 6455 Human Entrez Gene: 20405 Mouse Entrez Gene: 81922 Rat Omim: 601768 Human SwissProt: Q2KJA1 Cow SwissProt: Q99961 Human SwissProt: Q62419 Mouse SwissProt: O35964 Rat Unigene: 97616 Human Unigene: 1773 Mouse Unigene: 8762 Rat

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