Product Name	SF3A3
Chinese Name	选择性剪接因子3亚基3抗体
Alias	Pre mRNA splicing factor SF3a (60kD); Pre mRNA splicing factor SF3a; PRP 9; PRP9; PRPF 9; PRPF9; SAP 61; SAP61; SF3A3; SF3a60; Spliceosome associated protein 61; Splicing factor 3a subunit 3 60kDa; Splicing factor 3a subunit 3.
Research Area	Cell biology  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	59kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SF3A3: 21-120/501
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes subunit 3 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 3 interacts with subunit 1 through its amino-terminus while the zinc finger domain of subunit 3 plays a role in its binding to the 15S U2 snRNP. This gene has a pseudogene on chromosome 20. [provided by RefSeq, Jul 2008] Function: Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Subunit: Identified in the spliceosome C complex. Component of splicing factor SF3A which is composed of three subunits; SF3A3/SAP61, SF3A2/SAP62, SF3A1/SAP114. SF3A associates with the splicing factor SF3B and a 12S RNA unit to form the U2 small nuclear ribonucleoproteins complex (U2 snRNP). Interacts with SF3A1, through its N-terminal region. Subcellular Location: Nucleus speckle. Tissue Specificity: Ubiquitous. Similarity: Belongs to the SF3A3 family. SWISS: Q12874 Gene ID: 10946 Database links: Entrez Gene: 419608 Chicken Entrez Gene: 523250 Cow Entrez Gene: 475326 Dog Entrez Gene: 10946 Human Entrez Gene: 75062 Mouse Entrez Gene: 100512288 Pig Entrez Gene: 313583 Rat Entrez Gene: 495359 Xenopus laevis Entrez Gene: 446168 Zebrafish Omim: 605596 Human SwissProt: Q12874 Human SwissProt: Q9D554 Mouse Unigene: 77897 Human

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