Product Name	PREX1
Chinese Name	PREX1蛋白抗体
Alias	5)-dependent Rac exchanger 1; KIAA1415; OTTHUMP00000031228; P REX1; P Rex1 protein like; P-Rex1; Phosphatidylinositol 3,4,5 trisphosphate dependent Rac exchange factor 1; Phosphatidylinositol 3,4,5 trisphosphate dependent Rac exchanger 1; Phosphatidylinositol 3,4,5 trisphosphate dependent Rac exchanger 1 protein; Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein; Prex1; PREX1_HUMAN; PtdIns(3; PtdIns(3,4,5) dependent Rac exchanger 1; SET domain containing 6; Setd6
Research Area	Cell biology  immunology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	186kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PREX1: 1301-1400/1659
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene acts as a guanine nucleotide exchange factor for the RHO family of small GTP-binding proteins (RACs). It has been shown to bind to and activate RAC1 by exchanging bound GDP for free GTP. The encoded protein, which is found mainly in the cytoplasm, is activated by phosphatidylinositol-3,4,5-trisphosphate and the beta-gamma subunits of heterotrimeric G proteins. [provided by RefSeq, Jul 2008] Function: Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol-3,4,5-triphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. Subcellular Location: Cytoplasm > cytosol. Cell membrane. Mainly cytosolic. Some amount is apparently associated to the plasma membrane. Tissue Specificity: Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues. Similarity: Contains 1 DEP domain. Contains 1 DH (DBL-homology) domain. Contains 1 PDZ (DHR) domain. Contains 2 PH domains. SWISS: Q8TCU6 Gene ID: 57580 Database links: Entrez Gene: 57580 Human Entrez Gene: 277360 Mouse Entrez Gene: 311647 Rat Omim: 606905 Human SwissProt: Q8TCU6 Human SwissProt: Q69ZK0 Mouse Unigene: 153310 Human Unigene: 721980 Human Unigene: 34420 Mouse Unigene: 485065 Mouse Unigene: 224665 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PREX1) Polyclonal Antibody, Unconjugated (SL19671R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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