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Product Name phospho-Thymidine Kinase 1 (Ser13) Chinese Name 磷酸化胸苷激酶1抗体 Alias Thymidine Kinase 1 (phospho S13); p-Thymidine Kinase 1 (phospho S13); cytosolic; KITH_HUMAN; Thymidine kinase 1; Thymidine kinase 1 soluble; Thymidine kinase 1 soluble isoform; Thymidine kinase; Thymidine kinase cytosolic; TK 1; TK 2; TK1; Tk1a; Tk1b; TK2. Product Type Phosphorylated anti Research Area Cell biology Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Dog, Pig, Hamster, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 25kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthesised phosphopeptide derived from human Thymidine Kinase 1 around the phosphorylation site of Ser13: PG(pS)PS Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Thymidine Kinase (TK1) is a highly conserved phosphotransferase that is present in most living cells. Thymidine Kinase catalyzes the phosphorylation reaction: deoxythymidine + ATP = deoxythymidine 5'-phosphate + ADP; it is thus involved in the reaction chain to introduce deoxythymidine into the DNA. Thymidine kinase is required for the action of many antiviral drugs, such as azidothymidine (AZT), and is is also used to select hybridoma cell lines in the production of monoclonal antibodies. Thymidine Kinase has many clinical applications as it is only present in anticipation of cell division. Because of this, Thymidine Kinase can be used as a proliferation marker in the diagnosis, treatment, and follow-up of malignant diseases, especially hematological malignancies. Thymidine Kinase may be observed as a monomer, dimer, trimer or tetramer.
Subcellular Location:
Cytoplasm.
Post-translational modifications:
Phosphorylated on Ser-13 in mitosis.
Similarity:
Belongs to the thymidine kinase family.
SWISS:
P04183
Gene ID:
7083
Database links:Entrez Gene: 7083 Human
Entrez Gene: 21877 Mouse
Omim: 188300 Human
SwissProt: P04183 Human
SwissProt: P04184 Mouse
Unigene: 515122 Human
Unigene: 2661 Mouse
Unigene: 195325 Rat
Unigene: 216486 Rat
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