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Product Name Opticin Chinese Name Opticin蛋白抗体 Alias Oculoglycan; OPT; OPT_HUMAN; OPTC; Opticin. Research Area Cell biology Neurobiology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig, Cat, ) Applications ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 37kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Opticin: 201-300/332 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). [provided by RefSeq, Jul 2008]
Function:
Binds collagen fibrils.
Subcellular Location:
Secreted > extracellular space > extracellular matrix.Entrez Gene: 26254 Human Entrez Gene: 269120 Mouse Entrez Gene: 304802 Rat Omim: 605127 Human SwissProt: Q9UBM4 Human SwissProt: Q920A0 Mouse Unigene: 632468 Human Unigene: 59985 Mouse
Tissue Specificity:
Retina, iris, ligament, skin and fetal liver.
Post-translational modifications:
O-glycosylated.
Similarity:
Belongs to the small leucine-rich proteoglycan (SLRP) family.
SLRP class III subfamily.
Contains 6 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain.
SWISS:
Q9UBM4
Gene ID:
26254
Database links:Entrez Gene: 26254 Human
Entrez Gene: 269120 Mouse
Omim: 605127 Human
SwissProt: Q9UBM4 Human
SwissProt: Q920A0 Mouse
Unigene: 632468 Human
Unigene: 59985 Mouse
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