Product Name	Opticin
Chinese Name	Opticin蛋白抗体
Alias	Oculoglycan; OPT; OPT_HUMAN; OPTC; Opticin.
Research Area	Cell biology  Neurobiology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Guinea Pig, Cat, )
Applications	ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	37kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Opticin: 201-300/332
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Opticin belongs to class III of the small leucine-rich repeat protein (SLRP) family. Members of this family are typically associated with the extracellular matrix. Opticin is present in significant quantities in the vitreous of the eye and also localizes to the cornea, iris, ciliary body, optic nerve, choroid, retina, and fetal liver. Opticin may noncovalently bind collagen fibrils and regulate fibril morphology, spacing, and organization. The opticin gene is mapped to a region of chromosome 1 that is associated with the inherited eye diseases age-related macular degeneration (AMD) and posterior column ataxia with retinosa pigmentosa (AXPC1). [provided by RefSeq, Jul 2008] Function: Binds collagen fibrils. Subcellular Location: Secreted > extracellular space > extracellular matrix.Entrez Gene: 26254 Human Entrez Gene: 269120 Mouse Entrez Gene: 304802 Rat Omim: 605127 Human SwissProt: Q9UBM4 Human SwissProt: Q920A0 Mouse Unigene: 632468 Human Unigene: 59985 Mouse Tissue Specificity: Retina, iris, ligament, skin and fetal liver. Post-translational modifications: O-glycosylated. Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. Contains 6 LRR (leucine-rich) repeats. Contains 1 LRRNT domain. SWISS: Q9UBM4 Gene ID: 26254 Database links: Entrez Gene: 26254 Human Entrez Gene: 269120 Mouse Entrez Gene: 304802 Rat Omim: 605127 Human SwissProt: Q9UBM4 Human SwissProt: Q920A0 Mouse Unigene: 632468 Human Unigene: 59985 Mouse

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