Product Name	Selenoprotein M
Chinese Name	硒蛋白M抗体
Alias	Selenoprotein-M; Selenoprotein SelM; SELM; SELM_HUMAN; SelM protein; SEPM.
Research Area	Tumour  Cardiovascular  Cell biology  immunology  Developmental biology  Neurobiology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	14kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Selenoprotein M: 24-100/145
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Selenoprotein M is widely expressed and expressed highly in the mammalian brain. It is localized to the perinuclear structures (Golgi/ER). A growing body of evidence relates selenium to cancer prevention, immune system function, male fertility, cardiovascular disorder, control of the aging and neurodiseases process. Selenoproteins are thought to be responsible for the majority of these biomedical effects of selenium. Approximately 17 selenoproteins have been identified until now. Although the function of many selenoproteins are unknown, some play important roles in antioxidant mechanisms. It has been also implicated in the regulation of signaling pathways through catalysis of thiol/disulfide exchange. The roles of Selenoprotein M have not been clearly identified until present time. Function: May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation. Subcellular Location: Cytoplasm; perinuclear region. Endoplasmic reticulum Probable. Golgi apparatus Probable. Note: Localized to perinuclear structures corresponding to Golgi and endoplasmic reticulum. Similarity: Belongs to the selenoprotein M/SEP15 family. SWISS: Q8WWX9 Gene ID: 140606 Database links: Entrez Gene: 140606 Human Entrez Gene: 114679 Mouse Entrez Gene: 498398 Rat Omim: 610918 Human SwissProt: Q8WWX9 Human SwissProt: Q8VHC3 Mouse Unigene: 55940 Human Unigene: 34046 Mouse Unigene: 8166 Rat

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