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Product Name Securin 2 Chinese Name 垂体瘤转化蛋白2抗体 Alias Pituitary tumor transforming 2; Pituitary tumor transforming gene 2 protein; Pituitary tumor-transforming gene 2 protein; PTTG2; PTTG2_HUMAN; Securin-2. Research Area Tumour Cell biology immunology Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Horse, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 22kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Securin 2: 2-100/202 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail PTTG is overexpressed in Jurkat and is also detected in human thymus, testis and placenta. PTTG is mainly expressed in the cytoplasm and is also partially localized to the nucleus. Vertebrate PTTG regulates the separin Esp1, which promotes chromatid separation, to overcome the cohesive forces that hold sister chromatids together. This regulatory function of PTTG suggests that defective regulation of cohesion may contribute to cancer by promoting chromosome instability. Although vertebrate PTTG shares cell-cycle functions with its yeast securin counterparts Pds1p and Cut2, none share sequence homology
Subunit:
Cytoplasm. Nucleus.
Tissue Specificity:
Expressed at low levels in the pituitary, liver, spleen, prostate, testis, ovary, small intestine and colon. Also expressed in various pituitary, testicular, liver and ovarian tumors.
Similarity:
Belongs to the securin family.
SWISS:
Q9NZH5
Gene ID:
10744
Database links:Entrez Gene: 10744 Human
Omim: 604231 Human
SwissProt: Q9NZH5 Human
Unigene: 668806 Human
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