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Product Name SEC62 Chinese Name TransporterSEC62抗体 Alias Dtrp1; FLJ32803; hTP-1; HTP1; Membrane protein SEC62, S.cerevisiae, homolog of; OTTHUMP00000213390; sec62; SEC62 homolog (S. cerevisiae); SEC62_HUMAN; TLOC1; TP-1; Translocation protein 1; Translocation protein sec62. Research Area Cell biology Signal transduction Transporter Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, Rat, (predicted: Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 46kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SEC62: 251-350/399 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC63 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]
Function:
Required for preprotein translocation.
Subunit:
Part of a complex that contains SEC61, SEC62 and SEC63. Interacts with SEC61B.
Subcellular Location:
Endoplasmic reticulum membrane.
Similarity:
Belongs to the SEC62 family.
SWISS:
Q99442
Gene ID:
7095
Database links:Entrez Gene: 7095 Human
Entrez Gene: 69276 Mouse
Omim: 602173 Human
SwissProt: Q99442 Human
SwissProt: Q8BU14 Mouse
Unigene: 592561 Human
Product Picture Sample:
Lane 1: Thymus (Mouse) Lysate at 40 ug
Lane 2: Uterus (Mouse) Lysate at 40 ug
Lane 3: Thymus (Rat) Lysate at 40 ug
Lane 4: A431 (Human) Cell Lysate at 30 ug
Primary: Anti- SEC62 (SL19619R) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 46 kD
Observed band size: 48 kD
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