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Product Name SEC23IP Chinese Name SEC23相互作用蛋白抗体 Alias CDA II; CDAII; CDAN2; HEMPAS; Protein transport protein Sec23B; RP11-379J5.1; SC23B_HUMAN; Sec23 homolog B (S. cerevisiae); SEC23 related protein B; SEC23-like protein B; SEC23-related protein B; Sec23b; Transport protein SEC23B. Research Area Tumour Cell biology Developmental biology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species Rat, Rabbit, Sheep, (predicted: Human, Mouse, Cow, Horse, ) Applications IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 111kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SEC23IP: 811-910/1000 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the phosphatidic acid preferring-phospholipase A1 family. The encoded protein is localized to endoplasmic reticulum exit sites and plays a critical role in ER-Golgi transport as part of the multimeric coat protein II complex. An orthologous gene in frogs is required for normal neural crest cell development, suggesting that this gene may play a role in Waardenburg syndrome neural crest defects. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Feb 2011]
Function:
Plays a role in the organization of endoplasmic reticulum exit sites.
Subcellular Location:
Cytoplasmic vesicle > COPII-coated vesicle membrane. Endoplasmic reticulum.
Tissue Specificity:
Ubiquitously expressed with stronger levels detected in heart, liver and skeletal muscle.
Similarity:
Belongs to the PA-PLA1 family.
Contains 1 DDHD domain.
Contains 1 SAM (sterile alpha motif) domain.
SWISS:
Q9Y6Y8
Gene ID:
11196
Database links:Entrez Gene: 11196 Human
Entrez Gene: 207352 Mouse
SwissProt: Q9Y6Y8 Human
SwissProt: Q6NZC7 Mouse
Unigene: 435004 Human
Unigene: 667094 Human
Unigene: 297105 Mouse
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