Product Name	SEC16A
Chinese Name	TransporterSEC16A抗体
Alias	FLJ26737; KIAA0310; OTTHUMP00000022589; OTTHUMP00000022592; OTTHUMP00000022593; p250; Protein SEC16 homolog A; Protein transport protein Sec16A; RP11 413M3.10; SEC 16; SEC 16A; SC16A_HUMAN； SEC16; SEC16 homolog A (S. cerevisiae); SEC16 homolog A; SEC16L.
Research Area	Cell biology  Signal transduction  Transporter
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Dog, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	233kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SEC16A: 1101-1200/2179
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a protein that forms part of the Sec16 complex. This protein has a role in protein transport from the endoplasmic reticulum (ER) to the Golgi and mediates COPII vesicle formation at the transitional ER. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Feb 2013] Function: Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization. Subunit: SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. Interacts with SEC23A. Subcellular Location: Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Note=SAR1A activity is required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. Tissue Specificity: Ubiquitous. Expressed at higher levels in the pancreas. Similarity: Belongs to the SEC16 family. SWISS: O15027 Gene ID: 9919 Database links: Entrez Gene: 9919 Human Omim: 612854 Human SwissProt: O15027 Human

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