TEL: +86 571 56623320 EMAIL: [email protected]
Product Name SEC16A Chinese Name TransporterSEC16A抗体 Alias FLJ26737; KIAA0310; OTTHUMP00000022589; OTTHUMP00000022592; OTTHUMP00000022593; p250; Protein SEC16 homolog A; Protein transport protein Sec16A; RP11 413M3.10; SEC 16; SEC 16A; SC16A_HUMAN; SEC16; SEC16 homolog A (S. cerevisiae); SEC16 homolog A; SEC16L. Research Area Cell biology Signal transduction Transporter Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Dog, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 233kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SEC16A: 1101-1200/2179 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a protein that forms part of the Sec16 complex. This protein has a role in protein transport from the endoplasmic reticulum (ER) to the Golgi and mediates COPII vesicle formation at the transitional ER. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Feb 2013]
Function:
Defines endoplasmic reticulum exit sites (ERES) and is required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining an ERES. Required for normal transitional endoplasmic reticulum (tER) organization.
Subunit:
SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. Interacts with SEC23A.
Subcellular Location:
Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Note=SAR1A activity is required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation.
Tissue Specificity:
Ubiquitous. Expressed at higher levels in the pancreas.
Similarity:
Belongs to the SEC16 family.
SWISS:
O15027
Gene ID:
9919
Database links:Entrez Gene: 9919 Human
Omim: 612854 Human
SwissProt: O15027 Human
Scan Wechat Qrcode
Scan Whatsapp Qrcode