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Product Name SDPR Chinese Name 磷脂酰丝氨酸Binding proteinSDPR抗体 Alias Cavin 2; Cavin-2; Phosphatidylserine binding protein; Phosphatidylserine-binding protein; PS p68; PS-p68; Sdpr; SDPR_HUMAN; SDR; Serum deprivation response; Serum deprivation response protein; Serum deprivation-response protein. Research Area Cell biology Signal transduction Kinases and Phosphatases Binding protein Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, Rat, (predicted: Human, Cow, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 47kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SDPR: 231-330/425 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein is a substrate for protein kinase C (PKC) phosphorylation and recruits polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation.[provided by RefSeq, Sep 2009]
Function:
May play a role in targeting PRKCA to caveolae.
Subcellular Location:
Cytoplasm > cytosol. Membrane > caveola. Colocalizes with CAV1 to caveolae.
Tissue Specificity:
Highly expressed in heart and lung, and expressed at lower levels in brain, kidney, liver, pancreas, placenta, and skeletal muscle.
Post-translational modifications:
Phosphorylated on Ser residues.
Similarity:
Belongs to the PTRF/SDPR family.
SWISS:
O95810
Gene ID:
8436
Database links:Entrez Gene: 8436 Human
Entrez Gene: 20324 Mouse
Omim: 606728 Human
SwissProt: O95810 Human
SwissProt: Q63918 Mouse
Unigene: 26530 Human
Unigene: 480575 Mouse
Unigene: 203035 Rat
Product Picture Protein: heart(mouse) lysate at 40ug;
Primary: rabbit Anti-SDPR (SL19605R) at 1:300;
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 47 kD
Observed band size: 47 kD
Paraformaldehyde-fixed, paraffin embedded (Rat heart); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SDPR) Polyclonal Antibody, Unconjugated (SL19605R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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