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Product Name Nfe2l3 Chinese Name NFE2相关因子样蛋白3抗体 Alias erythroid derived 2; like 3; NF-E2-related factor 3; NF2L3_HUMAN; NFE2-related factor 3; Nfe2l3; NRF3; Nuclear factor; Nuclear factor erythroid 2-related factor 3. Research Area Cell biology transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Cow, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 76kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Nfe2l3: 481-580/694 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. [provided by RefSeq, Mar 2009]
Function:
Activates erythroid-specific, globin gene expression.
Subunit:
Heterodimer with MAFG, MAFK and other small MAF proteins that binds to the MAF recognition elements (MARE).
Subcellular Location:
Nucleus.
Tissue Specificity:
Highly expressed in human placenta and also in B-cell and monocyte cell lines. Low expression in heart, brain, lung, skeletal muscle, kidney and pancreas.
Similarity:
Belongs to the bZIP family. CNC subfamily.
Contains 1 bZIP domain.
SWISS:
Q9Y4A8
Gene ID:
9603
Database links:Entrez Gene: 9603 Human
Omim: 604135 Human
SwissProt: Q9Y4A8 Human
Unigene: 404741 Human
Unigene: 712898 Human
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