Product Name	NSL1
Chinese Name	着丝粒相关蛋白NSL1抗体
Alias	4833432M17Rik; AI451597; C1orf48; DC31; DC8; DKFZp566O1646; Gm105; Gm984; Kinetochore associated protein NSL1 homolog; Kinetochore-associated protein NSL1 homolog; MIS14; NSL1; NSL1, MIND kinetochore complex component, homolog (S. cerevisiae); NSL1_HUMAN.
Research Area	Cell biology  Chromatin and nuclear signals  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Sheep, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	32kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NSL1: 21-120/281
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. [provided by RefSeq, Jul 2014] Function: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. Subunit: Component of the MIS12 complex composed of MIS12, DSN1, NSL1/DC8 and PMF1. Interacts with CASC5. Subcellular Location: Nucleus. Chromosome > centromere > kinetochore. Associated with the kinetochore. Post-translational modifications: Phosphorylated upon DNA damage, probably by ATM or ATR. SWISS: Q96IY1 Gene ID: 25936 Database links: Entrez Gene: 25936 Human SwissProt: Q96IY1 Human Unigene: 497692 Human

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