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Product Name Uteroglobin Chinese Name 子宫珠蛋白抗体 Alias blastokinin; CC10; CC16; CCPBP; CCSP; Clara cell phospholipid binding protein; Clara cell phospholipid-binding protein; clara cell secretory protein; Clara cell specific 10 kD protein; Clara Cells 10 kDa Secretory Protein; OTTHUMP00000236107; SCGB1A1; Secretoglobin family 1A member 1; Secretoglobin, family 1A, member 1 (uteroglobin); UG; UGB; UP-1; UP1; Utg; Urinary Protein 1; Urine Protein 1; UTER_HUMAN; UTER_MOUSE; SCGB1A1. Research Area Cell biology immunology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Mouse, Rat, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 8kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse Uteroglobin: 51-96/96 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Uteroglobin belongs to the family of secretoglobins and is a secreted protein product of nonciliated bronchiolar Clara cells. There is convincing data suggesting it has phospholipase A2 inhibitory activity, as well as, a number of other immunomodulatory features including inhibition of interferon gamma signalling and Th1 vs. Th2 lymphocyte regulation. It was proposed as a potential peripheral marker of respiratory epithelial injury and bronchial dysfunction. Clara Cell Protein 16 concentrations have been determined in both serum and bronchoalveolar lavage fluid in numerous studies since 1994. In serum, its increase is associated with age, asbestos, nitrogen chloride and ozone exposure, sarcoidosis and high PEEP ventilation. Decreased serum CC16 levels are found after pulmonary resection, in silica-exposed workers, smokers and in asthma. Decreased CC16 concentrations were also found in the amniotic fluid of fetuses suffering from pulmonary hypoplasia caused by various mechanisms (diaphragmatic hernia, diabetic fetopathy, Turner and Down syndrome). In pleural effusions, the CC16 concentration appears to be associated with its diffusion from the lung as evidenced by high CC16 levels in cardiac pleural congestion.
Function:
Binds phosphatidylcholine, phosphatidylinositol, polychlorinated biphenyls (PCB) and weakly progesterone, potent inhibitor of phospholipase A2.
Subunit:
Homodimer; antiparallel disulfide-linked.
Subcellular Location:
Secreted.
Tissue Specificity:
Clara cells (nonciliated cells of the surface epithelium of the pulmonary airways).
Similarity:
Belongs to the secretoglobin family.
SWISS:
Q06318
Gene ID:
22287
Database links:Entrez Gene: 7356 Human
Entrez Gene: 22287 Mouse
Omim: 192020 Human
SwissProt: P11684 Human
SwissProt: Q06318 Mouse
Unigene: 523732 Human
Unigene: 2258 Mouse
Unigene: 2206 Rat
子宫珠蛋白(uteroglobin)是一种类固醇诱导的类似cell factor的多功能蛋白质,具有抗炎和免疫调节特性,它不仅在子宫内表达,而且可以在甲状腺,呼吸道,消化道,乳腺、胰腺、前列腺、脑垂体、睾丸等都有不同的表达。
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