Product Name	Vitronectin
Chinese Name	玻璃粘连蛋白抗体
Alias	Complement S Protein; Epibolin; S Protein; Serum Spreading Factor; V75; Vitronectin V10 subunit; VN; VNT; VTN; S-protein; Serum-spreading factor; V75; Vitronectin V10 subunit; VTNC_HUMAN.
literatures	Specific References  (4)     |     SL1932R has been referenced in 4 publications. [IF=18.962] Kui Chen. et al. Reversing the pathological microenvironment by radiocatalytic sensitizer for local orthotopic osteosarcoma radiotherapy enhancement. NANO TODAY. 2023 Feb;48:101739  IHC ;  Mouse.   PubMed:10.1016/j.nantod.2022.101739 [IF=7.6] Wang, Yang, et al. "Induced apoptosis of osteoblasts proliferating on polyhydroxyalkanoates." Biomaterials (2013).  Rat.   PubMed:23433672 [IF=3.382] Meng GL et al. Effect of zinc substitution in hydroxyapatite coating on osteoblast and osteoclast differentiation under osteoblast/ osteoclast co-culture. Regenerative Biomaterials, 2019, 1–11.  IF ;  Mouse.   PubMed:10.1093/rb/rbz001 [IF=1.889] Chao Gong. et al. Over-expression of vitronectin correlates with impaired survival in gastric cancers. Medicine. 2021 Aug 6; 100(31): e26766  IHC ;  Human.   PubMed:34397822
Research Area	Cardiovascular  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Cow, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	9/52kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Vitronectin: 381-478/478
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Vitronectin (also known as serum spreading factor, S protein of complement or epibolin) is one of the major multifunctional cell adhesive glycoproteins in mammalian plasma and serum. It is a monomeric acidic glycoprotein detected as a mixture of 75 kD and 65 kD polypeptides. Vitronectin binds to heparin, collagen, streptococci and variety of cultured cells. It also acts as an inhibitor of the complement cascade by binding to the C5b9 complex. Vitronectin promotes cell adhesion and spreading by binding through its cell attachment tripeptide Arg-Gly-Asp (RG-D), activity which is mediated by several different integrin receptors. Apart from the significance for identifying the molecule in the above situations, it also plays an important role in events such as embryonal development, deposition of vitronectin in a number of fibrotic disease states, carcinomas and metastases. Function: Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway (By similarity). Subunit: Monomer. Interacts with SERPINE1/PAI1 (By similarity). Subcellular Location: Secreted, extracellular space. Tissue Specificity: Plasma. Post-translational modifications: Sulfated on 2 tyrosine residues (By similarity). N- and O-glycosylated (By similarity). It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both. Similarity: Contains 4 hemopexin-like domains. Contains 1 SMB (somatomedin-B) domain. SWISS: P04004 Gene ID: 7448 Database links: Entrez Gene: 7448 Human Entrez Gene: 22370 Mouse Entrez Gene: 29169 Rat Omim: 193190 Human SwissProt: P04004 Human SwissProt: P29788 Mouse Unigene: 2257 Human Unigene: 3667 Mouse
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Mouse testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Vitronectin) Polyclonal Antibody, Unconjugated (SL1932R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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