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Product Name NOTO Chinese Name NOTO蛋白抗体 Alias floating head homolog; Homeobox protein notochord; Not; Not homeodomain protein; Noto; NOTO_HUMAN; notochord homolog (Xenopus laevis). Research Area Developmental biology Neurobiology transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Rabbit, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 27kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human NOTO: 121-220/251 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Transcription regulator acting downstream of both FOXA2 and T during notochord development. Required for node morphogenesis. Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function. Plays a role in regulating axial versus paraxial cell fate.
Subcellular Location:
Nucleus.
Similarity:
Contains 1 homeobox DNA-binding domain.
SWISS:
A8MTQ0
Gene ID:
344022
Database links:Entrez Gene: 384452 Mouse
SwissProt: Q5TIS6 Mouse
Unigene: 347883 Mouse
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