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Product Name NOL12/NOP25 Chinese Name 核仁蛋白12抗体 Alias C78541; dJ37E16.7; FLJ34609; MGC3731; Nol12; NOL12_HUMAN; Nop25; Nucleolar protein 12; Nucleolar protein of 25 kDa. Research Area Cell biology Neurobiology Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Cow, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 25kDa Cellular localization The nucleus Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human NOL12/NOP25: 121-213/213 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Nop25 is a 213 amino acid protein that localizes to the nucleolus and is thought to bind to 28S rRNA, possibly playing a role in the processing of rRNA molecules and in the subsequent assembly and maturation of ribosomes. The gene encoding Nop25 maps to human chromosome 22, which houses over 500 genes and is the second smallest human chromosome. Mutations in several of the genes that map to chromosome 22 are involved in the development of Phelan-McDermid syndrome, Neurofibromatosis type 2, autism and schizophrenia. Additionally, translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein BCR-Abl, a potent cell proliferation activator found in several types of leukemias.
Function:
May bind to 28S rRNA.
Subcellular Location:
Nucleus > nucleolus.
Similarity:
Belongs to the RRP17 family.
SWISS:
Q9UGY1
Gene ID:
79159
Database links:Entrez Gene: 79159 Human
Entrez Gene: 97961 Mouse
SwissProt: Q9UGY1 Human
SwissProt: Q8BG17 Mouse
Unigene: 632778 Human
Unigene: 157216 Mouse
Unigene: 17454 Rat
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