Product Name	NFKBIL1
Chinese Name	核因子κB抑制蛋白样蛋白1抗体
Alias	I-kappa-B-like protein; IkappaBL; IKBL; IKBL1_HUMAN; Inhibitor of kappa B-like protein; LST1; NF-kappa-B inhibitor-like protein 1; NFKBIL; Nfkbil1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1.
Research Area	Cell biology  immunology  Signal transduction  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	43kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human NFKBIL1: 81-180/381
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009] Function: May be a negative regulator of NF-kappa-B activation. Tissue Specificity: Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes. DISEASE: Defects in NFKBIL1 are a cause of susceptibility to rheumatoid arthritis (RA) [MIM:180300]. It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Similarity: Contains 2 ANK repeats. SWISS: Q9UBC1 Gene ID: 4795 Database links: Entrez Gene: 4795 Human Entrez Gene: 18038 Mouse Entrez Gene: 361794 Rat Omim: 601022 Human SwissProt: Q9UBC1 Human SwissProt: O88995 Mouse SwissProt: Q8R2H1 Rat Unigene: 2764 Human Unigene: 300795 Mouse Unigene: 38632 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (NFKBIL1) Polyclonal Antibody, Unconjugated (SL19224R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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