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Product Name CHRM5 Chinese Name 毒蕈碱型乙酰胆碱受体M5抗体 Alias Acetylcholine receptor muscarinic 5; AChR M5; CHKM5MR; Cholinergic receptor muscarinic 5; Chrm 5; CHRM5; HM 5; HM5; m5; M5R; MGC41838. literatures Specific References (2) | SL19110R has been referenced in 2 publications.[IF=2.624] Liyang Tong. et al. Topical bendazol inhibits experimental myopia progression and decreases the ocular accumulation of HIF‐1α protein in young rabbits. Ophthal Physl Opt. 2020 Sep;40(5):567-576 WB ; Rat.[IF=1.642] Tong L et al. Effects of topical pilocarpine on ocular growth and refractive development in rabbits. Eur J Ophthalmol. 2020 Jun 11;1120672120934962. IHC-P&WB ; Rabbit.Research Area Cell biology Neurobiology Signal transduction The cell membrane受体 The cell membrane蛋白 Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Pig, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 60kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human CHRM5: 461-532/532 <Cytoplasmic> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]
Function:
Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.
Subcellular Location:
Membrane; multi-pass membrane protein.
Similarity:
Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.
SWISS:
P08912
Gene ID:
1133
Database links:Entrez Gene: 1133 Human
Entrez Gene: 213788 Mouse
Omim: 118496 Human
SwissProt: P08912 Human
SwissProt: A2AHU3 Mouse
Unigene: 297624 Mouse
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