Product Name	SOCS2
Chinese Name	cell factor信号传导抑制蛋白2抗体
Alias	suppressor of cytokine signaling 2; suppressor of cytokine signaling SOCS2; CIS2; SOCS 2; Cish2; SSI-2; STATI2; SOCS2_HUMAN.
literatures	Specific References  (4)     |     SL1896R has been referenced in 4 publications. [IF=5.08] Letellier, E., et al. "Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer." British Journal of Cancer (2014).  IHC-P ;  Human.   PubMed:25025962 [IF=3.738] Zong, Jinxin. et al. Lithium Chloride Promotes Milk Protein and Fat Synthesis in Bovine Mammary Epithelial Cells via HIF-1α and β-Catenin Signaling Pathways. Biol Trace Elem Res. 2022 Jan;:1-16  WB ;  Bovine.   PubMed:35080710 [IF=3.56] Shin, Yoo-Jin, et al. "Expression of SOCS2 mRNA and protein in the ischemic core and penumbra after transient focal cerebral ischemia in rats." Cell and tissue research (2015): 1-15.  IHC-P ;  Rat.   PubMed:26563457 [IF=2.33] Zhu, Jian-guo, et al. "Expression of SOCSs in human prostate cancer and their association in prognosis." Molecular and cellular biochemistry (2013): 1-9.  WB ;  Human.   PubMed:23666742
Research Area	Cell biology  immunology  Neurobiology  Signal transduction  Apoptosis
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	23kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Socs2: 1-100/198
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012] Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Subunit: Interacts with IGF1 receptor, prolactin receptor and growth hormone (GH) receptor. Associates with the Elongin BC complex. Tissue Specificity: High expression in heart, placenta, lung, kidney and prostate. Similarity: Contains 1 SH2 domain. Contains 1 SOCS box domain. SWISS: O14508 Gene ID: 8835 Database links: Entrez Gene: 8835 Human Entrez Gene: 216233 Mouse Entrez Gene: 84607 Rat Omim: 605117 Human SwissProt: O14508 Human SwissProt: O35717 Mouse SwissProt: O88582 Rat Unigene: 485572 Human cell factor信号传导抑制蛋白(suppressor of cytokine signaling, SOCS)家族是一类由细胞产生并反馈性阻断cell factorSignal transduction过程的负性调节因子，SOCS2可抑制IL-6、LIF、OSM、INF-γ以及GH等多种cell factor的Signal transduction，对体内多种免疫反应的激活起调控作用。SOCS2异常表达与多种疾病的发病相关，在急慢性白血病、类风湿性关节炎、肝硬化和肝癌的发病中起重要作用；对Signal transduction，特别是JAKSTAT通路的负调控作用已被肯定。
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by microwave in sodium citrate buffer (pH6.0) ; Block endogenous peroxidase by 3% hydrogen peroxide for 30 minutes; Blocking buffer (3% BSA) at RT for 30min; Antibody incubation with (SOCS2) Polyclonal Antibody, Unconjugated (SL1896R) at 1:400 overnight at 4℃, followed by conjugation to the secondary antibody (labeled with HRP)and DAB staining.

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