Product Name	METT10D
Chinese Name	甲基样蛋白16抗体
Alias	2610100D03Rik; 2810013M15Rik; A830095F14Rik; AI846133; Methyltransferase 10 domain containing; Methyltransferase like 16; METT10D; MGC3329; OTTMUSP00000006473; Putative methyltransferase METT10D; RP23-174M12.2.
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit, Sheep, Guinea Pig, Cat, Chimpanzee, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	62kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human METT10D: 1-100/562
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	METT10D is a 562 amino acid protein that belongs to the METTL16/rlmF family and methyltransferase superfamily. A putative methyltransferase, METT10D exists as two alternatively spliced isoforms and undergoes phosphorylation in response to DNA damage, most likely by Atm or ATR. The gene encoding METT10D maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, and is linked to predisposition of cancers of the ovary, colon, prostate gland and fallopian tubes. Function: Probable methyltransferase. Similarity: Belongs to the methyltransferase superfamily. METTL16/RlmF family. SWISS: Q86W50 Gene ID: 79066 Database links: Entrez Gene: 468142 Chimpanzee Entrez Gene: 100765063 Chinese Hamster Entrez Gene: 480655 Dog Entrez Gene: 100734997 Guinea pig Entrez Gene: 79066 Human Entrez Gene: 67493 Mouse Entrez Gene: 360568 Rat SwissProt: Q86W50 Human SwissProt: Q9CQG2 Mouse

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