Product Name	MGLUR5
Chinese Name	代谢型谷氨酸受体5B抗体
Alias	MGLUR5B; Glutamate receptor metabotropic 5; GPRC1E; GRM 5; GRM5; Metabotropic glutamate receptor 5; mGlu5; mGluR5; mGluR5a; mGluR5b; Metabotropic glutamate receptor 5 variant F; Metabotropic Glutamate Receptor 5b; Metabotropic glutamate receptor 5 variant G; Metabotropic glutamate receptor 5 variant H; PPP1R86; GRM5_HUMAN;
Research Area	Cell biology  Neurobiology  Signal transduction  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Chicken, Cow, Horse, Sheep, Monkey, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	130kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MGLUR5: 431-530/1212 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Glutamate receptors constitute the principal excitatory neurotransmitter receptors in brain. Two classes of glutamate receptors exist: Ionotropic receptors, and metabotropic receptors (mGluRs). Metabotropic Glutamate Receptor 5b (GRM5) activity is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. The metabotropic glutamate receptor type 5 (mGlu5) is expressed in two splice variants, mGlu5a and mGlu5b, which differ in that mGlu5b has a 33-amino acid insert in the intracellular C-terminal domain. This receptor subtype is highly regulated, with higher levels found in developing animals. Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteKns) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. Subunit: The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Interacts with NCDN (By similarity). Subcellular Location: Cell Membrane Similarity: Belongs to the G-protein coupled receptor 3 family. SWISS: P41594 Gene ID: 2915 Database links: Entrez Gene: 2915 Human Entrez Gene: 108071 Mouse Entrez Gene: 24418 Rat Omim: 604102 Human SwissProt: P41594 Human SwissProt: Q3UVX5 Mouse SwissProt: P31424 Rat Unigene: 147361 Human Unigene: 29972 Rat
Product Picture	Sample: Cerebrum (Mouse) Lysate at 40 ug Primary: Anti-MGLUR5 (SL18801R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 130 kD Observed band size: 130 kD Sample: Cerebral cortex (Mouse) Lysate at 40 ug Hippocampus (Mouse) Lysate at 40 ug Primary: Anti-MGLUR5 (SL18801R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 130 kD Observed band size: 130 kD Sample: Lane 1: Cerebrum (Mouse) Lysate at 40 ug Lane 2: Cerebrum (Rat) Lysate at 40 ug Primary: Anti-MGLUR5 (SL18801R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: >140 kD Observed band size: 160 kD

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Totalgoods,subtotals:￥Checkout