Product Name	MESDC2
Chinese Name	中胚层分化蛋白2抗体
Alias	BOCA; KIAA0081; LDLR chaperone MESD; MESD; MESD_HUMAN; MESDC 2; mesdc2; Mesoderm development candidate 2; Mesoderm development protein; Renal carcinoma antigen NY REN 61; Renal carcinoma antigen NY-REN-61.
Research Area	Cell biology  Developmental biology  Stem cells  Cell differentiation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	23kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MESDC2: 51-150/234
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	MESDC2 is a 234 amino acid endoplasmic reticulum protein belonging to the MESD family. Considered a chaperone protein, MESDC2 specifically assists in folding beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs) through N- and C-terminal unstructured regions. MESDC2 modulates the Wnt pathway by chaperoning coreceptors LRP5 and LRP6 to the plasma membrane, and is essential for mesoderm induction and embryonic polarity. The gene encoding MESDC2 maps to human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes. Function: Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Subunit: Monomer By similarity. Interacts with LRP5; the interaction prevents LRP5 from forming aggregates and chaperones LRP6 to the plasma membrane. Interacts with LRP6; the interaction prevents LRP6 from forming aggregates and chaperones LRP6 to the plasma membrane. Subcellular Location: Endoplasmic reticulum. Similarity: Belongs to the MESD family. SWISS: Q14696 Gene ID: 23184 Database links: Entrez Gene: 23184 Human Omim: 607783 Human SwissProt: Q14696 Human Unigene: 578450 Human Unigene: 732380 Human

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