Product Name	MARS
Chinese Name	甲硫氨酸转运RNA合成酶抗体
Alias	cytoplasmic; Mars; Methionine tRNA ligase 1, cytoplasmic; Methionine tRNA ligase; Methionine tRNA synthetase; Methionine--tRNA ligase; Methionyl tRNA synthetase; Methionyl-tRNA synthetase; MetRS; MTRNS; SYMC_HUMAN.
Research Area	Cell biology  Transporter  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Pig, Cow, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	101kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human MARS: 1-100/900
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011] Subunit: Component of the multisynthetase complex which is comprised of a bifunctional glutamyl-prolyl-tRNA synthetase, the monospecific isoleucyl, leucyl, glutaminyl, methionyl, lysyl, arginyl, and aspartyl-tRNA synthetases as well as three auxiliary proteins, p18, p48 and p43. Subcellular Location: Cytoplasm. DISEASE: Infantile liver failure syndrome 2 (ILFS2) [MIM:615486]: A life-threatening disorder of hepatic function that manifests with liver failure in the first months of life. Clinical features include failure to thrive, hypotonia, intermittent lactic acidosis, aminoaciduria, hypothyroidism, interstitial lung disease, anemia, liver canalicular cholestasis, steatosis, and iron deposition. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family. Contains 1 GST C-terminal domain. Contains 1 WHEP-TRS domain. SWISS: P56192 Gene ID: 4141 Database links: Entrez Gene: 4141 Human Entrez Gene: 216443 Mouse Entrez Gene: 299851 Rat Omim: 156560 Human SwissProt: P56192 Human SwissProt: Q68FL6 Mouse Unigene: 632707 Human Unigene: 28173 Mouse

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