TEL: +86 571 56623320 EMAIL: [email protected]
Product Name phospho-MAPK6 (Ser189) Chinese Name 丝裂原活化蛋白激酶6抗体 Alias MAPK6 (phospho S189); p-MAPK6 (phospho S189); ERK-3; ERK3; ERK 3; ERK-3; Extracellular signal regulated kinase 3; Extracellular signal regulated kinase p97; Extracellular signal-regulated kinase 3; MAP kinase 6; MAP kinase isoform p97; MAPK 6; MAPK6; Mitogen activated protein kinase 6; Mitogen-activated protein kinase 6; MK06_HUMAN; p97 MAPK; p97-MAPK; PRKM6; Protein kinase mitogen activated 5; Protein kinase mitogen activated 6. literatures Specific References (1) | SL18672R has been referenced in 1 publications.[IF=4.645] Pin-Shi Ni. et al. Indirect regulation of HIPPO pathway by miRNA mediates high-intensity intermittent exercise to ameliorate aging skeletal muscle function. SCAND J MED SCI SPOR. 2023 Feb;: WB ; Rat.Product Type Phosphorylated anti Research Area Cell biology Signal transduction Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 83kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthesised phosphopeptide derived from human MAPK6 around the phosphorylation site of Ser189: HL(p-S)EG Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Mitogen-activated protein kinase (MAPK) signaling pathways involve closely related MAP kinases, including extracellular-signal-related kinase 3 (ERK 3, also designated PRKM6 and p97MAPK). Serum, growth factors and phorbol esters can initiate ERK 3 signaling pathways. Despite lacking a definitive nuclear localization sequence, ERK 3 constitutively localizes to the nucleus upon activation. p38 pathway activation-dependent upregulation of ERK 3 is independent of the status of p53, Bcl-2 and caspase-3 during cell stress and damage induced by proteasome inhibition, suggesting ERK 3 in part mediates intracellular defense or cell rescue. The human ERK 3 gene maps to chromosome 15q21.2 and encodes a 721 amino acid protein. Function : Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle.
Function:
Phosphorylates microtubule-associated protein 2 (MAP2). May promote entry in the cell cycle.
Tissue Specificity:
Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.
Post-translational modifications:
Dually phosphorylated on Thr-626 and Tyr-628, which activates the enzyme.
Similarity:
Belongs to the protein kinase superfamily.
CMGC Ser/Thr protein kinase family.
MAP kinase subfamily.
Contains 1 protein kinase domain.
SWISS:
Q16659
Gene ID:
5597
Database links:Entrez Gene: 5597 Human
Entrez Gene: 50772 Mouse
Omim: 602904 Human
SwissProt: Q16659 Human
SwissProt: Q61532 Mouse
Unigene: 411847 Human
Unigene: 480076 Mouse
Unigene: 88457 Rat
Scan Wechat Qrcode