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Product Name MAP4K3/GLK Chinese Name 生发中心激酶样激酶抗体 Alias Germinal center kinase like kinase; Germinal center kinase-related protein kinase; GLK; MAPK/ERK kinase kinase kinase 3; MAPKKKK3; MEK kinase kinase 3; MEKKK 3; MEKKK3; mitogen-activated protein kinase kinase kinase kinase 3; RAB8IPL1. Research Area Cell biology Signal transduction Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 101kDa Cellular localization The nucleus cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MAP4K3/GLK: 261-360/894 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Function:
May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway.
Subunit:
Interacts with SH3GL2. Interaction appears to regulate MAP4K3-mediated JNK activation
Subcellular Location:
Cytoplasmic and Nuclear
Tissue Specificity:
Ubiquitously expressed in all tissues examined, with high levels in heart, brain, placenta, skeletal muscle, kidney and pancreas and lower levels in lung and liver.
Similarity:
Belongs to the protein kinase superfamily.
STE Ser/Thr protein kinase family. STE20 subfamily.
Contains 1 CNH domain.
Contains 1 protein kinase domain.
SWISS:
Q8IVH8
Gene ID:
8491
Database links:Entrez Gene: 8491 Human
Entrez Gene: 225028 Mouse
Omim: 604921 Human
SwissProt: Q8IVH8 Human
SwissProt: Q99JP0 Mouse
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