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Product Name Malectin/MLEC Chinese Name Malectin蛋白抗体 Alias KIAA0152; Malectin; Mlec; MLEC_HUMAN. Research Area Cell biology Cell type markers Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 29kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Malectin/MLEC: 201-292/292 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail MLEC is a 292 amino acid single-pass type I membrane protein of the endoplasmic reticulum that belongs to the malectin family and is thought to play a role in N-glycosylation. MLEC may function as a carbohydrate-binding protein that preferentially binds Glc2-N-glycan. The gene encoding MLEC maps to human chromosome 12, which makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster, which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster, encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms which vary in severity depending on the extent of mosaicism. It is most severe in cases of complete trisomy.
Function:
Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation.
Subcellular Location:
Endoplasmic reticulum membrane.
Similarity:
Belongs to the malectin family.
SWISS:
Q14165
Gene ID:
9761
Database links:Entrez Gene: 9761 Human
Entrez Gene: 109154 Mouse
Entrez Gene: 569613 Zebrafish
Omim: 613802 Human
SwissProt: Q14165 Human
SwissProt: Q6ZQI3 Mouse
SwissProt: A9C3P0 Zebrafish
Unigene: 728853 Human
Unigene: 153963 Mouse
Unigene: 162140 Rat
Unigene: 148402 Zebrafish
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