Product Name	LRP5 + LRP6
Chinese Name	低密度Lipoprotein受体相关蛋白5+6抗体
Alias	BMND 1; BMND1; EVR 1; EVR 4; EVR1; EVR4; FLJ90062; FLJ90421; HBM; LDL Receptor Related Protein 5 + 6; Low density lipoprotein receptor related protein 5; Low density lipoprotein receptor related protein 5 precursor; Low density lipoprotein receptor related protein 6; Low density lipoprotein receptor related protein 6 precursor; LR 3; LR3; LRP 5; LRP 6; LRP 7; LRP7; OPPG; OPS; OPTA 1; OPTA1; VBCH 2; VBCH2.
Research Area	Tumour  Cell biology  Neurobiology  Signal transduction  The cell membrane受体  The cell membrane蛋白
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Sheep, )
Applications	IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	176kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LRP5 + LRP6: 521-620/1615
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization. Subcellular Location: Membrane; single-pass type I membrane protein Similarity: Belongs to the LDLR family. Contains 4 EGF-like domains. Contains 3 LDL-receptor class A domains. Contains 20 LDL-receptor class B repeats. SWISS: O75197 Gene ID: 4040 4041 Database links: Entrez Gene: 4040 Human Entrez Gene: 4041 Human Entrez Gene: 16973 Mouse Entrez Gene: 16974 Mouse Omim: 603506 Human Omim: 603507 Human SwissProt: O75197 Human SwissProt: O75581 Human SwissProt: O88572 Mouse SwissProt: Q91VN0 Mouse Unigene: 45360 Human Unigene: 584775 Human Unigene: 6347 Human

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