Product Name	LRP2BP
Chinese Name	低密度Lipoprotein相关蛋白2Binding protein抗体
Alias	DKFZp761O0113; FLJ44965; KIAA1325; LR2BP_HUMAN; LRP2 binding protein; LRP2-binding protein; Lrp2bp; Megalin binding protein; Megalin-binding protein; MegBP.
Research Area	Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	40kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LRP2BP: 101-200/347
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	LRP2BP is a 347 amino acid protein that contains one TPR repeat and six Sel1-like repeats. Localized to the plasma membrane and throughout the cytoplasm, LRP2BP interacts with megalin (also known as LRP2) and, via this interaction, is thought to regulate megalin function. Specifically, LRP2BP acts as a scaffold protein that, through its TPR motifs, assists in the sequestration and/or the release of transcription factors that influence megalin’s affects on endocytosis and hormone release. LRP2BP is expressed in colon, testis, small intestine and blood leukocytes, as well as in pancreatic adenocarcinoma cells, suggesting a possible role for LRP2BP in carcinogenesis. Two isoforms of LRP2BP exist due to alternative splicing events. Function: May act as an adapter that regulates LRP2 function. Subcellular Location: Cytoplasm. Detected in a vesicular staining pattern close to the plasma membrane and throughout the cytoplasm. Similarity: Contains 6 Sel1-like repeats. Contains 1 TPR repeat. SWISS: Q9P2M1 Gene ID: 55805 Database links: Entrez Gene: 55805 Human Entrez Gene: 67620 Mouse Entrez Gene: 290753 Rat Entrez Gene: 100073340 Zebrafish SwissProt: Q9P2M1 Human SwissProt: Q9D4C6 Mouse SwissProt: Q569C2 Rat SwissProt: A5PLI4 Zebrafish Unigene: 558513 Human Unigene: 383914 Mouse Unigene: 108662 Rat Unigene: 94415 Zebrafish

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