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Product Name LPHN3 Chinese Name 蛛毒素受体3抗体 Alias Calcium independent alpha latrotoxin receptor 3; Calcium-independent alpha-latrotoxin receptor 3; CIRL 3; CIRL-3; CIRL3; cl3 latrotoxin receptor; KIAA0768; Latrophilin 3; Latrophilin homolog 3 (cow); Latrophilin homolog 3; Latrophilin-3; Latrophilin3; LEC 3; LEC3; Lectomedin 3; Lectomedin-3; Lectomedin3; lph3; LPHN 3; Lphn3; LPHN3_HUMAN. Research Area Cell biology Neurobiology Signal transduction G protein-coupled receptor G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, Monkey, ) Applications ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 160kDa Cellular localization The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human LPHN3: 1171-1270/1447 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. [provided by RefSeq, Jul 2008]
Subcellular Location:
Cell membrane.
Post-translational modifications:
Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit.
Similarity:
Belongs to the G-protein coupled receptor 2 family.
LN-TM7 subfamily.
Contains 1 GPS domain.
Contains 1 olfactomedin-like domain.
Contains 1 SUEL-type lectin domain.
SWISS:
Q9HAR2
Gene ID:
23284
Database links:Entrez Gene: 23284 Human
Entrez Gene: 319387 Mouse
SwissProt: Q9HAR2 Human
SwissProt: Q80TS3 Mouse
Unigene: 28391 Human
Unigene: 570770 Human
Unigene: 273631 Mouse
Unigene: 461016 Mouse
Unigene: 203386 Rat
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