TEL: +86 571 56623320 EMAIL: [email protected]
Product Name LOXL1 Chinese Name 赖氨酰氧化酶样1抗体 Alias Lysyl oxidase like 1; LOL; LOXL1_HUMAN; LOXL; Lysyl oxidase homolog 1; Lysyl oxidase like 1; Lysyl oxidase like protein 1. Research Area Tumour Cell biology immunology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 53kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human LOXL1: 401-500/574 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
Function:
Involved in hearing. Required for normal function of hair cells in the inner ear.
Subcellular Location:
Secreted, extracellular space.
DISEASE:
Deafness, autosomal recessive, 77 (DFNB77) [MIM:613079]: A form of non-syndromic deafness characterized by preserved low-frequency hearing, and a trend toward mild to moderate mid-frequency and high-frequency hearing loss during childhood and adolescence. Hearing loss progresses to become moderate to severe at mid and high frequencies during adulthood.
Similarity:
Contains 14 PLAT domains.
SWISS:
Q08397
Gene ID:
4016
Database links:Entrez Gene: 4016 Human
Entrez Gene: 16949 Mouse
Omim: 153456 Human
SwissProt: Q08397 Human
SwissProt: P97873 Mouse
Product Picture
Scan Wechat Qrcode
Scan Whatsapp Qrcode