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Product Name LMOD2 Chinese Name 平滑肌蛋白LMOD2抗体 Alias C-LMOD; Cardiac leiomodin; Leiomodin 2 (cardiac); Leiomodin-2; LMOD2; LMOD2_HUMAN. Research Area Cardiovascular Cell biology Developmental biology Signal transduction Cytoskeleton Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Pig, Cow, Horse, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 62kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human LMOD2: 451-547/547 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Members of the Leiomodin protein family are closely related to the tropomodulin family of actin filament pointed end-capping proteins. Leiomodins are actin-binding proteins that act as strong filament nucleators in muscle cells. Leiomodin 1 is highly expressed in a variety of tissues that contain smooth muscle, therefore it is also known as smooth muscle Leiomodin, or SM-Lmod. Also designated C-Lmod, Leiomodin 3 is found in several types of fetal tissue and is involved in tropomyosin binding. Leiomodin 2, also known as C-LMOD or LMOD2, is a 547 amino acid protein that is specifically expressed in heart and skeletal muscles. Leiomodin 2 binds to tropomyosin and may block the elongation and depolymerization of actin filaments at their pointed end. Leiomodin 2 is encoded by a gene that is located near the hypertrophic cardiomyopathy locus CMH6 on chromosome 7, suggesting that Leiomodin 2 may be involved in that disease process. Leiomodin 2 is expressed as three alternatively spliced variants.
Function:
May block the elongation and depolymerization of the actin filaments at the pointed end.
Tissue Specificity:
Specifically expressed in heart and skeletal muscles. Not expressed in other tissues.
Similarity:
Belongs to the tropomodulin family.
Contains 1 WH2 domain.
SWISS:
Q6P5Q4
Gene ID:
442721
Database links:Entrez Gene: 442721 Human
Entrez Gene: 93677 Mouse
Omim: 608006 Human
SwissProt: Q6P5Q4 Human
SwissProt: Q3UHZ5 Mouse
Unigene: 592260 Human
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