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Product Name LMAN2L/VIPL Chinese Name 凝集素甘露糖Binding protein2样蛋白抗体 Alias DKFZp564L2423; Lectin mannose-binding 2-like; lectin, mannose binding 2 like; LMA2L_HUMAN; LMAN2 like protein; LMAN2-like protein; LMAN2L; MGC11139; VIP36 like protein [Precursor]; VIP36-like protein; VIPL. Research Area Cell biology immunology Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 38kDa Cellular localization cytoplasmic Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human LMAN2L/VIPL: 45-140/348 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Lectin mannose-binding 1, also designated vesicular integral-membrane protein (VIP36), and lectin mannose-binding 2, also designated ERGIC-53, comprise a family of membrane bound, ubiquitously expressed proteins involved in the selective transport of newly synthesized glycoproteins from the endoplasmic reticulum to the ER-Golgi intermediate compartment. VIPL (VIP36-like protein), also known as LMAN2L (lectin, mannose-binding 2-like), is a 348 amino acid single-pass type I membrane protein that localizes to the endoplasmic reticulum and Golgi apparatus. Containing one L-type lectin-like domain, VIPL is highly expressed in skeletal muscle and kidney, and is found at intermediate levels in heart, liver and placenta, and low levels in brain, thymus, spleen, small intestine and lung. VIPL is suggested to be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. VIPL may function as a regulator of ERGIC-53. VIPL exists a two alternatively spliced isoforms.
Function:
May be involved in the regulation of export from the endoplasmic reticulum of a subset of glycoproteins. May function as a regulator of ERGIC-53.
Subcellular Location:
Endoplasmic reticulum membrane. Golgi apparatus membrane. Predominantly found in the endoplasmic reticulum. Partly found in the Golgi.
Tissue Specificity:
Expressed in numerous tissues. Highest expression in skeletal muscle and kidney, intermediate levels in heart, liver and placenta, low levels in brain, thymus, spleen, small intestine and lung.
Similarity:
Contains 1 L-type lectin-like domain.
SWISS:
Q9H0V9
Gene ID:
81562
Database links:Entrez Gene: 81562 Human
Entrez Gene: 214895 Mouse
Omim: 609552 Human
SwissProt: Q9H0V9 Human
SwissProt: P59481 Mouse
Unigene: 655743 Human
Unigene: 287854 Mouse
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